A-kinase anchoring proteins (AKAPs) target PKA to specific substrates and distinct subcellular compartments providing spatial and temporal specificity for mediation of biological effects channeled ...

Choose from Protein Receptor stock illustrations from iStock. Find high-quality royalty-free vector images that you won't find anywhere else. Video Back Videos home Signature collection Essentials ...

G protein-coupled receptors (GPCRs ... Sevenless, the Drosophila homologue of ROS1 (dROS1) is a receptor tyrosine kinase essential for the differentiation of photoreceptor cells and activated ...

and the vast majority of these chemokine receptors belong to the G protein-coupled receptors (GPCRs). In this review, we summarize the signaling pathways by which neutrophil GPCR regulates chemotaxis ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified ... In cancers, all translocations involving ALK produce fusion proteins with constitutive tyrosine kinase activity ...

One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

Several mechanisms of resistance to erlotinib and gefitinib have been described in laboratory-based models (Figure 3).

Previous research has shown that stimulating a cell surface receptor called AXL can prompt EMT. Another protein in cancer cells, called TBK1, can also drive EMT and appears to be triggered by AXL.

She has spent most of her career counseling patients with diabetes, across all ages. Creatine and protein both play essential roles in the body. Creatine is necessary for energy production and ...

Hepatocellular carcinoma (HCC) is one of the most frequent malignancies with limited treatment options. Cabozantinib is an orally bioavailable multikinase inhibitor targeting c-MET, VEGFR2 and AXL ...