of the inhibitors are slow-onset tight-binding in nature and estimating the correct preincubation time can be a time-consuming exercise with potential for slowing down medicinal chemistry optimization ...

Sitala Bio Ltd. has prepared new indole derivatives acting as complement factor B (CFB) inhibitors. They are thus reported to be useful for the treatment of age-related macular degeneration, ...

Hemophilia A is classically caused by a congenital deficiency of factor VIII, but an acquired form due to inhibitors to factor VIII (FVIII) typically presents later in life. Patients who develop ...