Jan. 28, 2025 — A team of stem cell scientists have successfully used embryonic stem cell engineering to create a bi-paternal mouse -- a mouse with two male parents -- that lived until adulthood.
2025 — Scientists have developed an innovative solar-powered method to transform sewage sludge -- a by-product of wastewater treatment -- into green hydrogen for clean energy and single-cell ...
Results of a phase I/II clinical trial of CALEC, limbal epithelial cell grafts generated by an innovative and rigorously standardized manufacturing protocol, showing safety and feasibility for ...
as cell membrane stabilisers and permeability regulators that prevent hepatotoxic agents from entering hepatocytes; (iii) as promoters of ribosomal RNAsynthesis, stimulating liver regeneration ...
通过差异表达(DE)分析发现,血液和肿瘤组织中的免疫细胞在基因表达上存在显著差异。例如,肿瘤组织中 T 细胞的 CCL4 和 CCL5 表达更高。基因集富集分析(GSEA)显示,Toll 样受体(TLR)信号通路和 NOD 样受体信号通路在组织驻留 T 细胞和巨噬细胞中更活跃 ...
研究结论和讨论部分指出,GPR56 在 TBI 的病理生理过程中是一个保护因子。Gpr56 缺失会加重 TBI 后的运动和认知功能障碍、脑组织损失、BBB 损伤、神经炎症和神经元凋亡。GPR56 可能通过调节小胶质细胞的功能发挥其保护作用,具体机制可能是通过抑制 CCL3/4/5 - CCR5 信号通路来影响神经元自噬和凋亡。然而,该研究也存在一些局限性,如需要建立小胶质细胞特异性 Gpr56 ...
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