Introduction Coeliac disease (CD) is a common immune-mediated condition driven by aberrant adaptive CD4+ T cell responses to gluten. The cytotoxic CD8+ and γδ+ T cell response in the epithelium is ...

CD4 + Foxp3 + T regulatory cells (Treg) are required throughout life to maintain a ... There is clear indication that the generation of Treg is decisively influenced by the reactivity of their T cell ...

Methods CD4+ and CD8+ T cells were investigated in 25 enthesis samples using immunofluorescence, cytometrically, bulk RNAseq and quantitative real-time PCR following anti-CD3/CD28 bead stimulation to ...

S3). Immunohistochemical analysis showed a dense lymphocytic infiltration of the lamina propria positive for T-cell receptor (TCR) α, CD3, CD4, and granzyme B but which did not express TRBC1 ...

1Department of Pediatric Hematology and Oncology, Justus-Liebig University, Giessen, Germany. 2Department of Pathology, Boston Children´s Hospital, Boston, Massachusetts. 3Department of Pediatric ...

We wished to apply deep Hi-C sequencing to capture these shifts in 3D chromatin contacts in this terminal stage of CD4+ T-cell fate and correlate these with RNA abundance in the transcriptome (Bediaga ...

TCR data was integrated into the Seurat object using DALI 2.0.0 for downstream analysis. The selected Vα and Vβ TCR sequences were ordered as gBlocks (IDT) and subsequently cloned into the CD4 ...

为解决 IBD 患者 VTE 发病机制不明的问题，爱尔兰皇家外科医学院的研究人员开展组织因子相关研究。结果发现 CD4+TF+ T 细胞及活化 PC 的调节作用。这为理解 IBD 与 VTE 关系及开发新疗法提供依据，强烈推荐科研读者阅读。

为探究外周免疫系统在阿尔茨海默病（AD）发病中的作用机制，研究人员开展相关研究。结果发现其通过多种途径影响 AD 进程。该研究为 AD 治疗提供新靶点，对开发新疗法意义重大，推荐科研读者阅读。