but what was unclear was whether inhibiting this enzyme alone could reduce or stop cartilage loss in OA,” explains Little. ... Mmp13 knockout mice showed significant inhibition of cartilage ...

A recent study determined that bone area predicted the development of medial (inner side) and lateral (outer side) knee cartilage damage and loss of medial cartilage volume. Subchondral bone ...

Smoking did not appear to be associated with cartilage defects or loss of volume in the control individuals; however, smoking increased the risk of knee cartilage defects and loss of volume before ...

Baseline cartilage damage, higher Kellgren-Lawrence grade, greater pain during walking, higher lateral ground reaction force impulse, greater time spent lying and lower vertical ground reaction force ...

Results Patellofemoral cartilage thickness decreased −58 µm (95% CI −104 to –11 µm) over 5 years post-ACL rupture, with the greatest loss observed in trochlea during the first 2 years. Participants ...