近年来，CD40和CD40L逐渐走入科研的前沿，成为免疫系统研究的重要焦点。作为一种跨膜蛋白，CD40在抗原呈递细胞表面大放异彩，尤其在B细胞、巨噬 ...

近年来，CD40和CD40L逐渐走入科研的前沿，成为免疫系统研究的重要焦点。作为一种跨膜蛋白，CD40在抗原呈递细胞表面大放异彩，尤其在B细胞、巨噬细胞以及树突状细胞的激活过程中发挥关键作用。而其配体CD40L则主要依托于活化T细胞的表面，二者的相互作用在 ...

Tonix Pharmaceuticals has reported positive topline outcomes from its Phase I single ascending dose study of its ...

Eledon Pharmaceuticals has a promising anti-CD40L antibody for organ rejection prevention in transplantation. Learn more ...

Induction of CD40 mRNA expression was demonstrated by semiquantitative polymerase chain reaction. In the responder-PCLF cultures, IFN-γ alone caused a 1.5–5-fold increase in interleukin (IL)-8 ...

Further support for this concept comes from animal models of autoimmunity and transplantation, where treatments based on costimulation blockade, in particular CD40 ligand (CD40L)-specific ...

Novartis has finally given up on iscalimab after deciding that the anti-CD40 antibody is not worth pursuing in Sjögren’s syndrome. | Novartis has finally given up on iscalimab after deciding that the ...