为解决细菌异质性耐药（HR）机制及检测难题，柏林自由大学的研究人员对阴沟肠杆菌复合菌株展开研究。结果发现质粒上基因复制 - 扩增（GDA）导致对头孢他啶的 HR。该研究对理解 HR 机制和临床治疗意义重大，推荐科研读者阅读。

为解决发展中国家手术部位感染（SSIs）相关数据匮乏问题，埃塞俄比亚 Arba Minch General Hospital 研究人员研究 SSIs 流行、微生物谱及相关因素。发现 SSIs 患病率高且耐药严重，该研究对防控感染、合理用药意义重大，值得科研读者一读。

Analysis of data from 537 US hospitals reveals that ceftolozane-tazobactam and ceftazidime-avibactam are the most frequently ...

Review of data from the trial found that the vaccine was not sufficiently effective at preventing invasive E coli disease ...

NHSO approves six new drugs for insurance, enhancing treatments for tuberculosis, hepatitis C, and lymphoma, saving millions ...

Bacterial insertion sequences (IS) are small DNA segments (<2.5 kb) with a simple genetic organization. Most IS elements exhibit short terminal inverted repeat sequences (IR) and encode a transposase, ...

Doses and/or dosing intervals varied significantly for 12 antibiotics (amikacin, gentamicin, netilmicin, tobramycin, vancomycin administered as continuous infusion, ceftazidime, cloxacillin, oxacillin ...

Three of these six pathogens are antibiotic-resistant Gram-negative bacteria. Recently, antibacterial drugs against ESBL-producing Gram-negative bacteria accounted for ∼15% (2 out of 13) of all ...

in 0.45% sodium chloride injection SP 0.4 mL/min Ceftazidime Glaxo Wellcome 6039T86 2 g (80 mg/mL) in 0.45% sodium chloride injection SP 0.9 mL/min Ceftriaxone Roche 3829 2 g (66.7 mg/mL ...

编者按：多重耐药铜绿假单胞菌（MDR-PA）是一种对至少三种不同类别的抗菌药物（如β-内酰胺类、氨基糖苷类、喹诺酮类等）耐药的菌株，主要在医院环境中传播，常见于免疫功能低下或长期住院的患者。近年来，新型抗菌药物头孢他啶/阿维巴坦（CZA）和头孢洛扎/ ...