Centromeres are specific sites on chromosomes that are essential for mitosis and genome fidelity. This valuable research advance builds upon previous studies to convincingly show that the ...

Henikoff says. In a brand-new preprint, which is now in press at PNAS, he and his co-authors have proposed a new mechanism: that histone overexpression competes with proteins required to form stable ...

They analyzed how centromere-specific histone 3 (CENH3) influences the targeting and insertion of these elements, and explored the role of retrotransposons in centromere dynamics. Centromeres ...

They use a hybrid DNA sequence that combines CDEII and CDEIII as well as Widom 601 so they can make stable histones for biophysical studies (provided by the Widom sequence) and maintain features of ...

virginiana and F. chiloensis. However, the differences in centromere characteristics and evolutionary patterns between wild and cultivated octoploids have remained poorly understood. In a study ...

Mar. 27, 2025 — Scientists have uncovered a surprising role for calcium in shaping the building blocks of life. Their study reveals that calcium ions help determine the molecular 'handedness ...

virginiana and F. chiloensis. However, the differences in centromere characteristics and evolutionary patterns between wild and cultivated octoploids have remained poorly understood. In a study ...

Histone modification is an epigenetic mechanism that enables fine-tuning of gene expression. Mutation or dysregulation of proteins associated with histone modification (called “writers,” “erasers,” ...

The following autoantibodies were negative: SSA, SSB, double-stranded DNA, smith, ribonucleoprotein, SCL-centromere, histone, cyclic citrullinated peptide, anti-neutrophil cytoplasmic antibody, ...

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan ...