All iPSCs used for organoid generation were between passages 12 and 25. All cells and organoids were maintained in an incubator at 37°C and 5% CO 2. To generate 3D spheres, iPSCs were dissociated as ...

Top right, showing aggregates of mixed cell types but limited structural organization as achieved by condensation of pre-differentiated cells. Bottom left, representing the hepatobiliary organoids ...

9 This hypothesis posits that even current immature brain organoids, if they display complex neural activity patterns, may meet the criteria for consciousness attribution. Conversely, Global Workspace ...

Organoids are 3D cell culture models that more accurately reflect the structural and functional complexities of organs in vitro than traditional 2D cell culture methods. Generally derived from stem ...

Recent studies have utilized collections of organoids from different patients of a specific disease type to screen for sensitivity to novel compounds, drugs in clinical trials or those that have been ...

Here, we describe the development of mature, expandable AT2 organoids derived from human fetal lungs which are phenotypically stable, can differentiate into AT1-like cells, and are genetically ...

This could help clinical biologists study ... Dec. 9, 2024 — Researchers used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patient's ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. High-throughput measurement of cellular traction forces at the nanoscale remains a ...