and the inability of the base excision repair pathway to handle the damage to DNA that this induces. Five of the conditions (xeroderma pigmentosum, Cockayne's syndrome, trichothiodystrophy ...

Abstract: Compelling evidence indicates that proliferating cell nuclear antigen (PCNA) is an indispensable factor not only in DNA replication but in nucleotide excision repair (NER), alternative ...

many such conditions are found to have an etiological link to defects in one or more DNA repair pathways In a postmitotic organ such as the brain, the base excision repair pathway—a conserved ...

Researchers have uncovered answers that provide the detail to explain two specific DNA repair processes that have long been in question. Researchers from the University of Birmingham have ...

Research indicates that most organisms have multiple ligases dedicated to distinct DNA repair pathways, including nucleotide excision repair, base excision repair, and nonhomologous end joining for ...

DNA base lesions, such as incorporation of uracil into DNA or base mismatches, can be mutagenic and toxic to replicating cells. To discover factors in repair of genomic uracil, we performed a CRISPR ...

在临床和生物医学研究中，原位监测活细胞中相关 DNA 修复酶活性意义重大。研究人员构建双模式逻辑金纳米耀斑策略，对细胞内 APE1 和 FEN1 进行 OR/AND 逻辑成像。体外实验显示其生物相容性高，该策略在疾病诊断等方面有广阔应用前景。

Thymine DNA glycosylase (TDG) is a DNA glycosylase involved in base excision repair (BER) with a specialized role in the regulation of transcription through the maintenance of 5′-CpG-3′ sites via ...

The Summit supercomputer revealed how damaged strands of DNA are surgically repaired by a molecular pathway called nucleotide excision repair, or NER. NER’s protein components can change shape to ...

The PRRDetect algorithm identifies hidden DNA repair flaws in tumors It helps doctors choose effective therapies based on the tumor’s genetics This advancement brings personalized cancer care ...