Parkin ubiquitinates DRP1, leading to the proteasomal degradation of DRP1 and inhibiting mitochondrial ... and MICU. (3) LRRK2 blocks PERK mediated phosphorylation and activation of Parkin and MULAN, ...

Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding ...

Results Overexpression of HRES-1/Rab4 increased the mitochondrial mass of PBL (1.4-fold; p=0.019) and Jurkat cells (2-fold; p=0.000016) and depleted the mitophagy initiator protein Drp1 both in human ...

Following viral infection, the GTPase Drp1 wraps around certain sites of mitochondria ... recruitment of the E3 ligase Parkin, and Parkin activation via phosphorylation. Activated Parkin can ...

Mitochondrial fission is regulated primarily by Drp1, which is typically located in the cytoplasm. The activity of Drp1 is regulated by translocation as well as post-translational modifications, such ...

This important study identifies a new class of small molecules that activate the integrated stress response (ISR) via the kinase HRI. Convincing evidence, including the image analysis pipeline, ...

Our transcriptomic, epigenetic and genomic analyses on 19 immune cell subsets from peripheral blood mononuclear cell of patients with SLE revealed the importance of memory B cells via oxidative ...

Department of Chemistry, Chemical Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K.

Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan Medical Center, Ann Arbor. (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang ...