Mammoth Biosciences researchers have developed NanoCas, an ultracompact CRISPR nuclease, demonstrating its ability to perform ...

Objectives To investigate the effect of the L-arginine metabolism on arthritis and inflammation-mediated bone loss. Methods L-arginine was applied to three arthritis models (collagen-induced arthritis ...

In neonatal mammals, arginine is synthesized in the enterocyte, with either proline or glutamate as the dietary precursor. We have shown several times in piglets that proline is the only precursor ...

An inherited disorder affecting primarily boys, DMD is characterized by the progressive loss of skeletal, heart and lung muscle. It is caused by a mutation in the gene for the dystrophin protein, ...

L-arginine, an amino acid, is integral to the production of nitric oxide in our body, a molecule that contributes to the relaxation and dilation of blood vessels. As such, it is often sought-after ...

Muscular dystrophy is caused by a lack of certain proteins that are needed for muscle structure and function. Specifically, many of the types of MD are caused by a lack of a protein called dystrophin, ...

School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China Chinese Institute for Brain Research, Beijing 102206, China Changping Laboratory, Chinese Institute of Brain ...

This cover highlights the article A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung diseasee by Kyungtae Lim, ...

Background: Arginine deprivation therapy (ADT) hinders glioma cells’ access to nutrients by reducing peripheral blood arginine, showing great efficacy in various studies, which suggests it as a ...

A metabolite of particular interest is the amino acid L-arginine. L-arginine is a central metabolite for multiple cellular processes in macrophages and other cells. Aside from protein synthesis, ...