Sarah Vine and Andrew Pierce bring their own no-holds-barred opinions, insights and reaction (clue is in the title) to the biggest stories of the week. New episodes every Wednesday, wherever you ...

The most commonly mutated ALS-linked genes are reviewed with an emphasis on disease-causing mechanisms. The cellular processes involved in ALS pathogenesis are discussed, with evidence implicating ...

Highlights from the opening event of the second season of the E1 Powerboat Series in Jeddah in Saudi Arabia - this season features nine teams all owned by global superstars.

As an additional means of meeting these targets, the Kyoto Protocol introduced three market-based mechanisms, thereby creating what is now known as the carbon market. Stimulate sustainable development ...

Martin Odegaard opened the scoring after shocking defending from City Reuters Nevertheless, City's win over Chelsea saw them re-enter the Premier League top-four - with their title ambitions surely ...

The subsequent cascade of enzymatic reactions is tightly regulated to assure that complement is activated only ... of the complement pathways and their implication on physiology and pathology. This ...

The aim of this study is to identify and investigate the underlying epigenetic mechanisms of an aberrant ECM gene response to TGF-β1 from primary ... Patient demographics are provided in online ...

A change is called irreversible if it cannot be changed back again. Many chemical reactions are irreversible. In a chemical reaction, new materials are always formed. Sometimes these new materials ...

An MTF2-containing subcomplex of Polycomb Repressive Complex 2 promotes cell cycle progression through repression of D-type cyclin expression in certain cellular contexts.

Treatment of inherited genetic diseases of the brain remains an intractable problem. Methods to improve the distribution of enzymes that are injected or expressed from transduced cells will be ...

ORF3a, an accessory protein of SARS-CoV-2, mediates the transmembrane transport of water, leading to lysosome swelling. This function could, in principle, result in lysosome inactivation, a ...

Lactase deficiency (LD) is the failure to express the enzyme that hydrolyses lactose into galactose and glucose in the small intestine. The genetic mechanism of lactase persistence in adult Caucasians ...