Diagram of the process of autophagy from Forming a membrane and autophagosome to fuse phagosome and lysosome when contents of the vesicles are degraded and recycled. Autophagy defects linked to ...

We also investigated the effect of U18666A on CF555-dextran endocytosis. By examining the localization of CF-dex and Lamp1, we found that CF555 is present in the lysosome with U18666A treatment (Fig ...

Lysosomes are subcellular organelles that are mainly responsible for degradation of proteins internalized by cells by endocytosis and ... During the endosome–lysosome transition, the ...

Hence, pharmacological upregulating lysosome machinery via targeting TFEB represents a promising approach to treat NPC and related lysosomal storage diseases, and provides the possibility of TFEB ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Toll-like receptor 4 (TLR4) signaling at the ...

Fcα/μR also mediated primary B lymphocyte endocytosis of IgM-coated Staphylococcus aureus. Thus, Fcα/μR is involved in the primary stages of the immune response to microbes. Figure 3 ...

A closer look at gene expression in cells derived from the animal models showed that STING also increased the activity of genes associated with lysosome repair and new lysosome generation.

Edited by Peter Devreotes, Johns Hopkins University School of Medicine, Baltimore, MD; received December 23, 2024; accepted January 17, 2025 ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes.

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