When the COVID-19 pandemic first began, we saw how quickly the SARS-CoV-2 virus evolved. New variants emerged with mutations ...

This week’s column completes a two-part series looking into heterosis (hybrid vigour) as part of a ‘Crossbreeding 101 ...

An effective HIV-1 vaccine must therefore elicit antibodies that can neutralize many variants of the virus. While broadly neutralizing antibodies (bnAbs) have been isolated from HIV-1 infected ...

Gregor Mendel's principles of inheritance form the cornerstone of modern genetics. So just what are they? When looking at the figure, notice that for each F 1 plant, the self-fertilization ...

在生物学的神秘世界里，基因之间的相互作用一直是科学家们关注的焦点。其中，上位性（epistasis），也就是不同基因座（locus，指基因在染色体上的位置）上的等位基因（allele，基因的不同形式）之间的相互作用，在生物的各种现象中起着极为关键的作用。

Three multi-point mutants demonstrated higher affinity than the wild type, but only P29T and G134R exhibited positive epistasis, resulting in the creation of a double-point mutant with superior ...

随着生物技术的不断发展，小分子药、小核苷酸药及抗体药等靶向抗肿瘤药物的开发已取得重大进展，其中小核苷酸药及ADC类药物更是多家药企开发抗肿瘤药物的热门首选。体外代谢试验是检验药物稳定性及安全性的必要手段，而肝溶酶体是小核苷酸药及ADC类 ...