The classic estrogen receptor signaling pathway occurs through the entry of estrogen into the cell, translocation to the nucleus, interaction with the nuclear estrogen receptor (ER) α or β ...

ER+/PR+ breast cancer, common and hormone-responsive, offers a better prognosis and is key in treatment research advancements.

Estrogen functions through binding of two different ... Inhibiting bone resorption via an effect on the RANK/RANKL/OPG signaling pathway (see following section); Enhancing bone formation by ...

Dr. Kevin Kalinsky discusses the role of targeted therapy and clinical decision-making in managing estrogen-driven, ...

A combination, triplet therapy that targets cancer cells from within and without caused tumors to shrink or stabilize in ...

ERG positivity, an early molecular alteration in prostate cancer development, exhibits differing prevalence between African American and White patients. Nevertheless, the extent of race-based ...