The authors provide convincing evidence indicating that two receptor tyrosine kinases (RTKs), CAD96CA and FGFR1, modulate the genomic effects of JH by phosphorylating ... two RTKs and potential ...

In conclusion, KLX exhibits protective effects against EndMT and atherosclerosis by activating the FGFR1/MAP4K4 pathway and suppressing the integrin β1/TGFβ signaling pathway. This study's ...

They have two other molecules, TYRA-200, an oral FGFR1/2/3, and TYRA-430 ... the risk of liver toxicity due to the blockade of FGF19 signaling through FGFR4. On the other hand, FGFR3 inhibition ...

Later, Ang2 upregulation enhances vascular endothelial growth factor receptor-2 (VEGFR-2), forming a pro-angiogenic microenvironment. Persistent fibroblast growth factor receptor 1 (FGFR1) signaling ...

Rubenstein for his comments, suggestions, and edits. We are grateful to Professor Hua Han for sharing the Rbpj floxed mice, and Professor Jean M. Hebert for sharing Fgfr1/2/3 floxed mice. This study ...

While it is understood that this fusion activates tyrosine kinase signaling, the mechanisms of transformation and importance of perturbation of EBF1 activity remain unknown. EBF1 is a nuclear ...

Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China Introduction: TDI01 is a novel and highly selective ROCK2 inhibitor, which provides a potential valuable candidate ...

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Centre for 3D models of Health and Disease, Division of Surgery and Interventional Science, University College London, London W1W 7TY, U.K. Centre for 3D models of Health and Disease, Division of ...