Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. ...

Several years ago, few biochemists or cell biologists would have predicted that the complexity of the pathways involved in protein degradation ... all the important aspects. In addition, most ...

Things often seem either black or white within the targeted protein degradation (TPD) space. The biology behind degrading therapeutic targets that are difficult or dangerous to inhibit is well ...

It has several advantages over traditional approaches, such as microbial fermentation ... chaperons that aid protein-folding and also minimizes risks of protein degradation. Proteins directed ...

Large scale manufacturing of proteins for use in food, agriculture, pharmaceuticals, biologics, textiles, and personal care products currently relies on costly fermentation processes that contribute ...