More information: Thomas A. Hope et al, SNMMI Procedure Standard/EANM Practice Guideline for Fibroblast Activation Protein (FAP) PET, Journal of Nuclear Medicine (2024). DOI: 10.2967/jnumed.

In the present study, we evaluated the role of S100A4 in fibroblast activation in systemic sclerosis (SSc). Methods The expression of S100A4 was analysed in human samples, murine models of SSc and in ...

SNMMI Procedure Standard/EANM Practice Guideline for Fibroblast Activation Protein (FAP) PET Feasibility, Tolerability, and Preliminary Clinical Response of Fractionated Radiopharmaceutical Therapy ...

The purpose of the study was to characterise whether CK2 contributes to the pathologic activation of fibroblasts in patients with SSc and to evaluate the antifibrotic potential of CK2 inhibition.

Fibroblast growth factors (FGFs) signal through FGF receptor tyrosine ... renal phosphate reabsorption and downregulates vitamin D activation. FGF23 is broadly implicated in human disease ...

Fibroblasts are the most common cell type in connective tissue. They can be compared to 'nature's stitches', holding together ...

FIGURE 1. The molecular mechanisms of cardiac fibrosis. Note: Akt, protein kinase B; EGF, epidermal growth factor; ERK, extracellular signal-regulated kinase; FGF, fibroblast growth factor; HO-1, heme ...

providing insights into how fibroblast activation can influence tumor progression. The model opens up new possibilities for studying fibroblast-driven effects in diverse settings, which is crucial for ...

Thomas H. Sisson, Toby M. Maher, Iyabode O. Ajayi, Jessie E. King, Peter D.R. Higgins, Adam J. Booth, Rommel L. Sagana, Steven K. Huang, Eric S. White, Bethany B ...

Figure 1. Overview of cellular steps leading to cardiac fibrosis. Following injury, cardiac fibroblasts are activated and transdifferentiated into myofibroblasts to replace dying cardiomyocytes. Dying ...

providing insights into how fibroblast activation can influence tumor progression. The model opens up new possibilities for studying fibroblast-driven effects in diverse settings, which is crucial for ...