For many years this was the world that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhabited. Seemingly relegated to serving as a reliable loading control for western blots and other such ...

Macbecin II was identified as a compound that upregulates MHC-I expression, enhancing immune-mediated cancer cell killing. In ...

自2019年Nature杂志首次报道血清素能够进入细胞核使组蛋白H3Q5发生共价修饰以来，这一领域的研究便如火如荼地展开。从情绪调控到神经传递，从代谢平衡到肿瘤微环境，这种新型翻译后修饰正掀起生命科学的“魔丸革命”。

基于转录组学探讨欧前胡素改善乳腺癌多柔比星耐药的机制李意婷1，董伟2，梁新丽2，王虎1，邱雨美1，丁小云1，张浩1，鲍会云1，李娴晰1，汤喜兰1（1.江西科技师范大学药学院；2.江西中医药大学现代中药制剂教育部重点实验室）摘要 ...

从器官层面来看，胃部作为塑料摄入的初始部位，其合成的蛋白质如胃蛋白酶原 A5（PGA5）和胃动蛋白 - ...

[…] we provide the aging field with lists of tissue-specific age-invariant genes as well as 9 pan-tissue age-invariant genes for use in normalization ...

衰老是一个由基因活性变化驱动的过程，但来自耶鲁大学医学院和Altos Labs的研究人员，由第一作者John T. González和通讯作者Albert T. Higgins-Chen领导，发现了一组在衰老过程中保持不变的基因。这一发现可能提高衰老研究的准确性，并为某些基因保持不变而其他基因衰退的原因提供见解。

Following injury, many organs are capable of rapid regeneration of necrotic tissue to regain normal function. In contrast, ...

总的来说，该研究发现长寿个体在血浆中表现出较少的全身性缺氧相关代谢物和更多的抗氧化和抗炎代谢物，从而具有更健康的临床表型，包括更低的炎症参数以及更好的葡萄糖-脂质代谢和肝肾功能。简而言之，年轻的红细胞功能和代谢使长寿个体能够更好地对抗外周组织缺氧、炎 ...

The membrane was then coated with a solution of TBS-T containing primary antibody against XO, GAPDH, cleaved N-terminal GSDMD, cleaved-Caspase-1 or NLRP3, and incubated overnight at 4°C with gentle ...