Rather, several distinct signaling mechanisms appear to contribute ... mechanism of GPCR mediated ERK activation, other pathways contribute to GPCR-mediated ERK activation in many cell types.

As the largest family of cell surface receptors, GPCRs account for over one-third of drug screening efforts. Inositol-1-phosphate (IP1) is a metabolite of Gq signaling and has been shown to be very ...

With overlapping focuses on Biological Chemistry, Chemical Biology, and Molecular Pharmacology, our research group takes the reductionist approach when dissecting biological processes at the ...

Key GPCR family receptors that are related to diseases. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or ...

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments-water, lipid membranes, or other condensed phases-are critical to their ...

As G protein-coupled receptors (GPCRs) are widely distributed throughout the body, including the pain transmission pathway and descending inhibition pathway, the development of novel neuropathic pain ...