Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7365, United States ...

Among proteins, the G-protein-coupled receptors (GPCRs), are central to how cells sense and respond to external stimuli. To carry out their signaling, GPCRs rely on a delicate interplay between ...

As G protein-coupled receptors (GPCRs) are widely distributed throughout the body, including the pain transmission pathway and descending inhibition pathway, the development of novel neuropathic pain ...

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Janus kinase 2 (JAK2) and signal transducers and activators of transcription 5 (STAT5) are involved in the proliferation, differentiation, and survival of mammary gland epithelial cells. Dysregulation ...

to the orthosteric site on G protein-coupled receptor (GPCR), which involves different domains, mainly the transmembrane and extracellular ones. This leads to the activation of multiple signaling ...

Rather, several distinct signaling mechanisms appear to contribute ... mechanism of GPCR mediated ERK activation, other pathways contribute to GPCR-mediated ERK activation in many cell types.