1 Xuzhou Clinical College of Xuzhou Medical University, Division of Cardiology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China 2 Xuzhou Institute of Cardiovascular Disease, Xuzhou, Jiangsu, China ...

在此，研究揭示了 S - 棕榈酰化（S-palmitoylation）通过谷胱甘肽过氧化物酶 4（Glutathione peroxidase 4，GPX4）对铁死亡（ferroptosis）的关键调控作用，GPX4 是一种减轻脂质过氧化的关键酶。研究人员鉴定出，在多种肿瘤中高表达的 S - 酰基转移酶 —— 含锌指 DHHC 结构域 ...

细胞实验方面，利用细胞活力检测（CCK-8 assay）、细胞凋亡和周期检测、细胞迁移和侵袭实验 ... 证明 DIM 通过调节 AHR 表达诱导 NSCLC 细胞发生铁死亡。 DIM 通过调节 AHR/NRF2/GPX4 轴诱导 NSCLC 细胞铁死亡：分子对接结果显示，DIM 与 AHR 具有良好的结合能力。

Protein concentration was determined using a BCA assay kit. Approximately 30 µg of proteins were separated by SDS-PAGE ... ab32503), Anti-FACL4 (Abcam, ab205197), Anti-GPX4 (Abcam, ab125066), ...

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China ...

Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130021, P. R. China Department of ...