Post-treatment with KW decreased the levels of caspase-12, GRP78, C/EBP homologous protein, phosphorylation of IRE-I, x-box-binding protein 1s, as well as phosphorylation of proline-rich receptor-like ...

However, the excessive accumulation of misfolded proteins recruit GRP78 away from all three ER stress sensors ... expression and signal transducer and activator of transcription 3 (STAT3) ...

Department of Chemistry, Chemical Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K.

靶向神经酰胺转移蛋白通过 GRP78-ATF6-CHOP 轴使急性髓系白血病对 FLT3 抑制剂敏感 在癌症研究领域，鞘脂类物质，如神经酰胺，在调节癌细胞死亡过程中发挥着至关重要的作用。癌细胞中神经酰胺生成和代谢的缺陷，会促进肿瘤细胞的存活，并增强其对化疗的抗性。

PERK induces phosphorylation of eIF2α ... protein 1 (XBP-1), which increases the expression of the chaperone GRP78 (17). The other promotes the degradation of specific mRNAs (18).

Membranes were incubated with primary antibodies (anti-RIPK1, anti-MLKL, anti-Caspase-3, anti-TNFα, anti-phospho-IRE1α, anti-IRE1α, anti-GRP78 and anti-CHOP) overnight at 4°C, washed with TBS-T (0.1% ...

Correspondence to Professor Daozhang Cai and Dr Xiaochun Bai, Department of Orthopedics, Academy of Orthopedics - Guangdong Province, Orthopedic Hospital of Guangdong Province, The Third Affiliated ...

Smooth muscle cells (SMCs) regulate blood flow distribution via vasoconstriction mediated by α-ARs (α-adrenergic receptors). Plasma membrane cholesterol accumulation affects α 1-AR signaling and ...

Could nanotechnology improve exercise performance? Evidence from animal studies Lima, M.R. Moreira, B.J. Bertuzzi, R. Lima-Silva, A.E.