【导读】雌激素受体阳性（ER+）乳腺癌约占病例的 70%。靶向雌激素的内分泌疗法是 ER+ 乳腺癌的一线疗法。然而，约有一半的患者会对这些疗法产生耐药性，从而导致生存率降低。

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P.R. China University of the Chinese ...

From the GO analysis, we screened the upregulated differentially expressed genes and identified key pathways, including mitophagy, autophagy, ferroptosis, apoptosis, nonalcoholic fatty liver disease ...

Ferroptosis, a form of regulated cell death, plays a crucial role in the development of fibrosis; however, its role in the mechanisms of keloid formation remains poorly understood. Methods: This study ...

它溶于水、稀醇、液氨和甲基甲酰胺，而不溶于醇、醚和丙酮。生物体内只有GSH才具有生理活性，而GSSG需还原后才能发挥其重要的生理功能。GSH在高水分活性下不易保存，只有将水分活性控制在0.3以下才能够长期稳定保存。有研究显示，在含有GSH的维生素C水 ...

Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered ...

However, the liver's robust antioxidant defenses, including glutathione (GSH) and vitamin E, question the widespread applicability of ferroptosis as a primary mode of cell death in DILI.

Figure 4. GSH, a pivotal element, plays a crucial role in both the ferroptosis and cuproptosis pathways. SLC7A11 facilitates the transport of cystine into cells, which is then used for the synthesis ...