But the neurons from the LHA send projections to the brain reward circuitry also contain other factors apart from Ghrelin such as the expressing orexins, MCH, and 26RFa (see Model 3). Orexin neurons ...

This manuscript by Tesmer and colleagues uses fiber photometry recordings, sophisticated analysis of movement, and deep learning algorithms to provide compelling evidence that activity in hypothalamic ...

Additional 12-month-old homozygous Tg-SwDI mice and 5xFAD mice (Jax # 034848) were added to compare the types and distribution patterns of Aβ deposits and the numbers of orexin and MCH neurons in ...

Idorsia has become the first drugmaker in the EU to claim approval for a drug for chronic insomnia in the dual orexin receptor antagonist class, ahead of rival drugs from Merck & Co and Eisai.

For 2025, Alkermes plans to generate over $200 million in EBITDA while advancing its orexin program, particularly ALKS 2680, which is enrolling Phase 2 studies for narcolepsy. These studies are ...

Circadian rhythms in mammals are regulated by a master circadian pacemaker located in the hypothalamic suprachiasmatic nucleus (SCN), which coordinates rhythmic processes throughout the organism ...

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jpcb.4c06767.

Leptin is a hormone – a chemical messenger that helps different body parts work together. Leptin sends a signal to your brain that helps you feel full and less interested in food. You may hear ...

The body of a local man was recovered from the Klamath River earlier this week.

There are a significant number of words, phrases and acronyms that appear when talking about race and ethnicity which often change depending on the context of the conversation. Language is ...