High-grade glioma, an aggressive form of pediatric and adult brain cancer, is challenging to treat given the tumor location, ...

Brain tumors remain the most common cause of death from childhood cancer. Paediatric high-grade gliomas (pHGG) in particular are a mostly fatal disease group with a median survival time of less than ...

A study shows that high-grade glioma tumor cells harboring DNA alterations in the gene PDGFRA responded to the drug avapritinib, which is already approved by the United States Food and Drug ...

The significance of the two studies from Vienna becomes clearer when you know that the first is about the most insidious type ...

Using glioma tumor samples, researchers looked for genetic mutational signatures, finding one previously associated with ...

Firefighters might face a higher risk of brain cancers caused by exposure to chemicals in fire extinguishers, a new ...

Brain tumours remain the most common cause of death from childhood cancer. Paediatric high-grade gliomas (pHGG) in particular are a mostly fatal disease group with a median survival time of less than ...

Methods: A total of 40 glioma specimens were collected in this study. We extracted data from The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and Gene-Expression Omnibus (GEO) ...

Identifying splicing-related neoantigens in gliomas opens new avenues for immunotherapy, enhancing treatment strategies for this challenging brain tumor.

One of the most significant developments in glioma treatment is the discovery of IDH (Isocitrate Dehydrogenase) mutations, which are found in many lower-grade gliomas and some glioblastomas.