Glucagon-Like Peptide-2 (GLP-2 ... particles that transport fats in the bloodstream—through a signaling pathway involving neuronal nitric oxide synthase (nNOS)[2]. This pathway is essential ...

This review provides an overview of TLR signaling pathways and their regulators and discusses how TLR signaling, directly and indirectly, regulates cell-mediated immunity. In addition, we also discuss ...

Because mutations of this receptor or its ligand lead to autoimmune disorders such as systemic lupus erythematosus (SLE) and cancers, CD95 and CD95L were initially thought to play a role in immune ...

Although gut microbiota and lipid metabolites have been suggested to be closely associated with type 2 diabetes mellitus (T2DM), the interactions between gut microbiota, ...

New research explores the wide world of the positives, and potential drawbacks, of new obesity medications. And each brings a new consideration for physicians.

7 refine our understanding of the signaling effects of oncogenic KRAS. Rather than activating multiple effectors, mutant KRAS signals preferentially through the RAF–MEK–ERK pathway ...

This important study investigates the signaling pathways regulating retinal regeneration. Convincing evidence shows that the sphingosine-1-phosphate (S1P) signaling pathway is inhibited following ...

Liraglutide, a GLP-1 receptor agonist, has been shown to effectively lower glucagon levels and promote ... and insulin signaling pathways. Despite being in early research stages, bile acid ...

In muscle tissue, Activin interacts with the Activin RII receptor, triggering intracellular signaling pathways. Activin RII phosphorylates Activin RI, which activates the Smad2/3 signaling pathway.

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In fact, the more we learn about biochemical pathways that this class of drug targets, the more it seems that we have opened the door to a dramatically improved understanding of metabolism and the ...