SPRAVATO® acts on the brain's glutamate pathway, a new approach in the treatment of depression. The exact mechanism by which esketamine exerts its antidepressant effect is not fully understood.

Researchers have discovered that, in mice, exposure to UV light activates a molecular pathway that increases production of the brain chemical glutamate, heightening the animals’ ability to learn and ...

“Preclinical data strongly suggest that the glutamate pathway could be of importance in the treatment of glioblastoma,” notes Grossman. The 72 patients who were given talampanel as part of ...