The enzymes with significant changes of acetylation level in the PCOS group were highlighted in a metabolic pathway diagram (Figure 5A). In glycolysis, five enzymes involved in the reactions for the ...

ATP, the primary energy source, is generated through glycolysis and cellular respiration ... AKG has been shown to promote protein synthesis through the mTORC1-dependent pathway, which regulates ...

Hepatic ischemia-reperfusion injury (IRI) is a common and unavoidable complication associated with liver transplants that may ...

Our approach outperforms alternatives by striking an optimal balance, evaluating enzyme expression at pathway level, rather than either single-reaction or whole-network levels. Enhanced flux potential ...

A pioneering study has revealed that increased stiffness in the extracellular matrix (ECM) of spinal discs impairs energy ...

This study provides a valuable approach to image and analyze in vivo metabolic flux through glucose turnover kinetics in glioblastoma ... Effectively characterizing these features would improve the ...

Following injury, many organs are capable of rapid regeneration of necrotic tissue to regain normal function. In contrast, ...

Findings reveal macrophages' role in immune modulation through bacterial metabolites, paving the way for improved therapies ...

and other related metabolic syndromes. The c-Jun N-terminal kinase (JNK) pathway plays a crucial role in response to dietary stressors, and it was demonstrated that the inhibition of the JNK pathway ...

1Department of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, China. 2Shandong Engineering Research Center of ...