Findings reveal macrophages' role in immune modulation through bacterial metabolites, paving the way for improved therapies ...

Following injury, many organs are capable of rapid regeneration of necrotic tissue to regain normal function. In contrast, ...

Hepatic ischemia-reperfusion injury (IRI) is a common and unavoidable complication associated with liver transplants that may ...

A pioneering study has revealed that increased stiffness in the extracellular matrix (ECM) of spinal discs impairs energy ...

Agilent User Guides were followed to perform all metabolic assays. Briefly, the Real-Time ATP Rate Assay evaluates total adenosine triphosphate (ATP) production alongside specific contributions from ...

TP53 Y220C mutations in advanced urothelial bladder cancer (UBC): A genomic landscape study. This is an ASCO Meeting Abstract from the 2025 ASCO Genitourinary Cancers Symposium. This abstract does not ...

These findings further support the notion that PRMT1 plays a role in mediating metabolic reprogramming by enhancing glycolysis and reducing mitochondrial oxygen consumption. Figure 4. PRMT1 Changes ...

This manuscript describes the important role of PRMT1 in the metabolic reprograming in AMKL. In a PRMT1-driven AMKL model, only cells with high PRMT1 expression induced leukemia, which was effectively ...

Our approach outperforms alternatives by striking an optimal balance, evaluating enzyme expression at pathway level, rather than either single-reaction or whole-network levels. Enhanced flux potential ...

1Department of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, China. 2Shandong Engineering Research Center of ...