Conceptual and recent experimental data link cccDNA formation to cellular DNA repair, which is increasingly appreciated as a critical interface between cells and viruses. Together with new in vitro ...

HBV复制率高，每天约产生1万亿个完整的病毒颗粒，以及只含HBsAg的亚病毒颗粒，后者不能复制，也不能感染，但其含量较完整的HBV高1 000～100 ...

Objective The HBV HBx regulatory protein is required for transcription from the covalently closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both viral and host ...

HBV在肝内形成的共价闭合环状DNA（HBV cccDNA）库的持续存在与HBV慢性持续性感染以及慢性乙型肝炎（CHB）难以治愈密切相关。HBV cccDNA的彻底清除不仅 ...

近年来，国内外大量研究均已表明，HBV在肝内形成的共价闭合环状DNA（HBV cccDNA）库的持续存在与HBV慢性持续性感染以及慢性乙型肝炎（CHB）难以治愈密切相关。HBV cccDNA的彻底清除不仅是判定HBV感染彻底治愈的重要指标，也是终止CHB进展为肝硬化、肝细胞癌（HCC ...

Intrahepatic cccDNA was quantified and its association with liver inflammation was analyzed. Liver inflammation was assessed using the Ishak-modified histological activity index (HAI). Biochemical and ...

but they cannot eradicate chronic hepatitis B (CHB) because of their incapacity to eliminate endocellular covalently closed circular DNA (cccDNA). Thus, there is a necessity to develop new strategies ...

目前，先降低病毒负荷、再免疫调节治愈的路径已经达成共识。由此可见，我们依然需要新的更强的DAA药物。在慢性乙肝治疗的新药开发上，我国政府部门的态度则更加务实。如中国国家药监局药品审评中心（CDE）最近批准了已知HBVDNA复制作用更加明显的NA类新药 ...

The definition and clinical use of common HBV serological markers are shown in Table 2. HBsAg is the hallmark of HBV infection and is the first serological marker to appear in acute hepatitis B.

Viral hepatitis is a major danger to public health. According to WHO’s 2024 Global Hepatitis Report, viral hepatitis deaths ...

Hepatitis B (sometimes referred to as hep B) is a liver infection caused by the hepatitis B virus (HBV). It typically causes symptoms like stomach pain, dark urine, fatigue, fever, jaundice (yellowing ...

Dagger; Approximately five copies = 1 IU. ALT: Alanine aminotransferase; HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus. IgM anti-HBc Presence with high index value during acute HBV ...