University of Illinois at Chicago, Chicago, IL.

The definitive diagnosis was established through extensive histopathological examination and immunohistochemistry, which demonstrated the tumour’s unique immunoprofile, showing strong positivity for ...

贝泰妮研究院在皮肤衰老模型中发现，胶原流失与HMGB1释放相关，HMGB1是导致皮肤衰老的核心，同时，HMGB1表达失衡 会导致皮肤敏&老恶性循环加速。 为了打破这一循环，薇诺娜凭借 14 年医研积累，专为敏感肌定制科学抗老方案，推出银核霜、银核精华两大新品。

Patients treated with trastuzumab deruxtecan + pertuzumab had a statistically significant and clinically meaningful improvement in PFS compared with standard of care. Topline results were ...

Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China ...

这一过程始于铁死亡细胞中脂质过氧化产物的积累，这会导致细胞膜不稳定，最终细胞破裂。细胞死亡后，如 ATP、高迁移率族蛋白 B1（HMGB1）和线粒体 DNA（mtDNA）等 DAMPs 释放到细胞外环境，成为免疫细胞的强效信号。这些 DAMPs 与巨噬细胞、树突状细胞等免疫 ...

膜破裂机制??：Gasdermin D（GSDMD）介导的孔道形成不仅释放IL-1β，更通过胞内内容物外泄（如ATP、HMGB1）扩大炎症反应。??治疗新靶点??：针对特定代谢酶（如ACOD1）或干扰素受体（IFNAR）的干预在动物模型中显示协同治疗效果。 （注：全文严格基于原文事实性内容 ...

This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...