Vogt produce histamine synthetically by removing the ... 1972—James Black discovers the H2 receptor and characterizes its antagonist, burimamide. 1999—Researchers at a subsidiary of Johnson ...

providing they can enter the CNS. Researchers have proposed a range of solutions, and receptor-mediated transport (RMT) is now widely regarded as “one of the most efficient and safest routes to ...

Receptor cells detect a change in the environment (a stimulus) and start electrical signals along neurons. These move towards the central nervous system (CNS). The CNS is the brain and spinal cord.

Receptor in the skin detects a stimulus (the change in temperature). Sensory neuron sends electrical impulses to a relay neuron, which is located in the spinal cord of the CNS. Relay neurons ...

The startup's in-house projects include GM-1020, a small-molecule NMDA receptor channel blocker – the mechanism of action for ketamine – which is in phase 2a clinical development for major ...

PIPE-791 is an LPA1 receptor antagonist in clinical development for idiopathic pulmonary fibrosis, progressive multiple sclerosis and chronic pain, and PIPE-307 is a selective inhibitor of the M1 ...