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突破白血病治疗困境:基于新抗原的 TCR-T 细胞疗法带来新曙光
急性髓系白血病(AML)和高危骨髓增生异常综合征(MDS)治疗面临诸多挑战,免疫疗法效果不佳。研究人员针对 RNA 剪接因子突变开展研究,识别出一系列错剪衍生新抗原及相关 TCR。这为白血病免疫治疗提供新思路,有望改善患者预后。
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