yahoo.com Objectives Targeted therapies for systemic sclerosis (SSc) and other fibrotic diseases are not yet available. We evaluated the efficacy of heat shock protein 90 (Hsp90) inhibition as a novel ...

Breast cancer is a major disease with high morbidity and mortality in women worldwide. Increased use of imaging biomarkers has been shown to add more information with clinical utility in the detection ...

Immune checkpoint inhibitors (ICIs) block inhibitory molecules, such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1), or its ligand, programmed cell ...

Biogen acquired the Hsp90 modulator in 2023 through its buyout ... treating Parkinson’s by targeting LRRK2, with BIIB122, an inhibitor of the protein, remaining in the biotech’s phase 2 ...

Multiple myeloma (MM), which is caused by the transformation and uncontrolled proliferation of blood cells that normally produce antibodies 1, is the second most common haematological cancer ...

Off-label uses outside of the drug's formal Food and Drug Administration (FDA) approval can include migraines and other health issues. Researchers continue to investigate ACE inhibitor use in treating ...

We are a world-leading cancer research institute, a charity, and a member institution of the University of London. Public donations and clinical partnerships are helping us to make the discoveries ...

Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg 79104, Germany ...

Researchers have developed an artificial intelligence-based model that can help pathologists grade certain lung cancer tumours and predict patients’ outcomes.