Crypt-base-columnar cells are continuously dividing intestinal stem cells that generate IECs, which are composed by distinct specialised cell types that play different functions: Enterocytes (in ...

The HKUMed research team developed world’s first biobank of ‘intestinal metaplasia’ organoid models to study early cancer development, helping detect early warning signs of stomach cancer.

We spatiotemporally pattern these cues using photoinduced degradation, viscoelasticity, and bond formation to study how intestinal stem cell colonies respond to alterations in geometric confinement, ...

the stem cells reside at the base of the crypt-like domains in the in vitro organoids. The preparation of Clevers and colleagues lacks stromal cells, which are thought to make up the intestinal ...

The epithelial lining of our intestine is organized in a crypt-villi architecture and serves many essential functions including maintenance of barrier, digestion and nutrient absorption. Due to the ...

Lab-grown intestinal organoids mimic gut structures, including crypts, which are crucial for gut regeneration as they are home to stem cells. However, the exact mechanical processes driving crypt ...

An IBEC-led study describes the development of an innovative method to control the formation of crypt-like structures ... and differentiation of intestinal epithelial tissue.