Antibodies and related products are the fastest growing class of therapeutic agents ... proof-of-concept of the clinical efficacy of new protein scaffolds with different pharmacological properties ...

mRNA therapies are one of the hottest drug classes today, but scientists need to solve issues of stability, immunogenicity ... protein that it encodes. mRNA can only exert its therapeutic effects ...

Additionally, biochemical assays tend to struggle to characterize the complexity of the structure of protein aggregates.

Existing therapeutic options can usually not stop ... the USP5 level was significantly reduced. We also found the protein aggregates that we had observed in the mice in the diseased heart muscle ...

Protein therapeutics add another layer of complexity to the problem. Components in protein therapeutics may form aggregates in response to pharmaceutically-relevant time scales or under stress ...