Pattern recognition receptors (PRRs) are expressed by cells ... a potential dual sensor linked to pro-inflammatory responses, interferon induction and resistance to viral infection, as evidenced ...

Each cytokine acts through its own receptor on target cells, and these receptors include members ... to amplify redox signalling and the type I interferon response in macrophages.

Traditionally, screening for latent TB infection (LTBI) is done using the tuberculin skin test (TST). Interferon-gamma release assays (IGRAs) are now increasingly being used for diagnosis of LTBI, but ...

Recent work has revealed that interferon-induced ADP-ribosylation (ADPr), which can be reversed by a SARS-CoV-2-encoded hydrolase, is enriched within a condensate. However, the identity of the ...

Once within the tumour, it stimulates receptors on immune cells to mount an attack on the cancer. Recombinant interferon alfa-2b was originally developed by Biogen as a therapy for various forms ...

This therapy employs systemic administration of the tissue hormone interferon-I combined with ... an active substance that activates the innate receptors TLR7/8 and used to treat basal cell ...

Get Instant Summarized Text (Gist) A novel drug compound has been identified that selectively activates delta opioid receptors, offering pain relief without the dangerous side effects associated ...

We previously reported that low-grade PDAC cells display high expression of interferon regulatory factor 1 (IRF1), a pivotal transcription factor of the interferon (IFN) system, suggesting ...

Apr. 4, 2025 — A novel cell therapy approach using cord blood-derived natural killer (NK) cells pre-complexed with AFM13, or acimtamig, a CD30/CD16A bispecific antibody, was safe and generated ...

Data reviewed in this article demonstrate that both interferon-ß-1a (IFNß-1a) and interferon-ß-1b (IFNß-1b) show a dose-response relationship in multiple sclerosis at current clinical doses.

HONG KONG, China I April 18, 2025 I Akeso, Inc. (9926.HK) ("Akeso" or the "Company") is pleased to announce that ebdarokimab, an investigational monoclonal ...