In various cellular models, including iPSC-derived neural cells, immune cells and fibroblasts, PD-associated mutant LRRK2 G2019S increases mtDNA damage that is abrogated by either gene editing to ...

Run a brief analysis at the single-cell level, let’s use the common Seurat pipeline. set.seed(12345) sc <- CreateSeuratObject(counts = sc.counts, project = proj.name, meta.data = sc.meta) sc ## An ...

The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought.

Feb. 10, 2025 — Influenza A virus particles strategically adapt their shape -- to become either spheres or larger filaments -- to favor their ability to infect cells depending on environmental ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.

Interestingly, many of these lines of defense have been found to be altered in neurodegenerative diseases such as PD and HD. Current knowledge and further elucidation of the novel pathways that ...

You're paying less per line each month than you would with a single line of the best cell phone plan overall. And that helps keep your monthly wireless bill manageable. There's something else to ...

Scientists have been working for decades to create synthetic cells that mimic key functions of biological cells. The challenge has been to make the artificial cells dynamic, responsive ...

Induced pluripotent stem cells (iPSCs), which greatly circumvent the ethical issue of human embryonic stem cells (ESCs), can be induced to differentiate to dopaminergic (DA) neurons, and hence be used ...

a machine learning tool that can provide heterogeneity-resolved scRT profiles, and apply it to a large single-cell dataset that includes tumours, cell lines, and patient-derived xenografts.

Figure 4: Characterization of the low-SiaLev Jurkat cell lines. Figure 5: Mutational analysis of low-SiaLev cell lines. Figure 6: Molecular characterization of the high-SiaLev cell line.

Design 27 primary PDAC tumours were employed for genetic analysis and development of tumour models. Tumour tissue was used for derivation of xenografts and cell lines. Exome sequencing was performed ...