The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.orglett.5c00233.

Adverse drug reactions (ADRs) represent a significant challenge to public health, affecting millions of patients worldwide. As pharmacological therapies become more complex and personalized, it ...

University of Lodz, Faculty of Chemistry, Department of Organic Chemistry, Tamka 12, 91-403 Lodz, Poland ...

Sarah Vine and Andrew Pierce bring their own no-holds-barred opinions, insights and reaction (clue is in the title) to the biggest stories of the week. New episodes every Wednesday, wherever you ...

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...

Lissencephaly is a severe neurodevelopmental disease often caused by mutations in the Dcx gene. Using a human cellular model of lissencephaly, the authors report that DCX restricts neuronal ...