The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the ...

With only a few exceptions, these drugs were discovered by screening in animal models which do not discriminate on the basis of mechanism of action. Over the last 35 years, over 34,000 ...

Generally, treatment of fungal infections is challenging as a limited number of antifungal drugs are available. Emerging of resistance among fungi and its increasing trend in recent decades along with ...

"For decades, clinicians have relied on a handful of antifungal classes, with few mechanisms of action and significant limitations due to spectrum of activity, drug toxicities, or drug-drug ...

However, despite LAG3’s role in immune exhaustion and the great potential of LAG3 inhibition as treatment, much remains unknown about its biology, particularly its mechanism of action. This review ...

The University of Exeter has launched a new round of funding to tackle the growing global challenge of fungal antimicrobial resistance (fAMR). The FAILSAFE project (Fungal AMR Innovations for ...

It is possible that the substituents effects observed for the benzodiazepine’s antifungal activity are due to the increase in lipophilicity promoted by the presence of methyl group, which provides ...

College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, P. R. China ...

Chitosan, a naturally occurring polysaccharide derived from chitin, has demonstrated significant potential as an antiviral ...