Calcium homeostasis plays an essential role in maintaining excitation–contraction coupling (ECC) in cardiomyocytes, including calcium release, recapture, and storage. Disruption of calcium homeostasis ...

Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and extracellular matrix ...

This comprehensive approach enables a deeper understanding of the interactions between electrical excitation and metabolic processes in cardiac cells, particularly during drug testing and under ...

Seizure-related cardiac arrhythmias are frequently reported and have been implicated as potential pathomechanisms of Sudden Unexpected Death in Epilepsy (SUDEP). We attempted to identify clinical ...

ed.ac.uk Myocardial injury is common in patients without acute coronary syndrome, and international guidelines recommend patients with myocardial infarction are classified by aetiology. The universal ...

Cardiac arrest (when the heart stops beating) interrupts circulation, causing brain cells to start dying in less than five minutes of the brain going without needed oxygen in the blood. The ...

AAV-Navβ1 gene therapy effectively reduces seizures and prolongs life in a mouse model of SCN1B-linked Dravet syndrome, ...

With the advancements of molecular genetics and the identification of mutations in the genes encoding the cardiac ryanodine receptor and cardiac calsequestrin 2 in patients with CPVT, the central role ...

duke-nus.edu.sg Despite prompt reperfusion by primary percutaneous coronary intervention (PPCI), the mortality and morbidity of patients presenting with an acute ST-segment elevation myocardial ...

That sneaky upward creep is referred to as cardiac drift, and we’re here to help you understand it and keep it from derailing your run. Cardiac drift is a physiological phenomenon where ...