Current medications can only alleviate symptoms but cannot halt disease progression. Studies have confirmed that both dopaminergic neuronal loss and α-Syn aggregation are associated with necroptosis ...

College of Food science and Engineering, Jilin University, Changchun, Jilin 130062, China State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research, Ministry of Education, ...

To do so the authors compared different NUP proteins and assessed their function by analyzing nuclear leakage and resistance to induction of nuclear damage and the associated necroptosis. The authors ...

As cells are infected by microorganisms, they can pre-emptively die to prevent the replication and spreading of the pathogen. Cell death that is associated with the presence of pathogen-associated ...

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention ...

New research has revealed that removing a protein called gasdermin D can protect the liver from inflammation and scarring in ...

Apoptosis occurs in a wide range of human diseases. In animal models of virus-induced disease, apoptosis correlates with viral titre and can be found in areas targeted by viral infection, which ...

为探究免疫细胞导致心肌细胞损伤的机制，河北医科大学研究人员开展 “MLKL–Mediated Necroptosis Predominantly Contributes to Immune?Associated Myocardial Damage” 研究。结果表明，MLKL 介导的坏死性凋亡主导免疫细胞诱导的心肌损伤，抑制该过程或可治疗心肌炎，为心肌炎治疗提供新方向。

与增殖细胞不同，神经元中 RIPK3 的激活不会诱导坏死性凋亡（necroptosis），而是产生抗病毒转录反应。研究表明，在皮质神经元中，RIPK3 依赖的转录反应需要其他含 RHIM 结构域的蛋白 RIPK1（受体相互作用蛋白激酶 1）和 TRIF（TIR 结构域衔接蛋白诱导 IFN-β），这 ...

本研究像一把钥匙，打开了理解ACLF多器官损伤机制的新大门。同时，再次敲响警钟：长期酗酒不仅导致肝硬化，还可能引发全身多器官连锁衰竭。即便肝脏“暂时扛住”，肾、脑等器官也可能默默承受不可逆损伤。

The brain is organized into systems and networks of interacting components. The functional connections among these components give insight into the brain's organization and may underlie some cognitive ...

Introduction: Cell pacing is a fundamental procedure for generating action potentials (AP) in excitable tissues. Various pulse shapes have been proposed for this purpose, with the aim of either ...