Chemoresistance is the most significant challenge affecting the clinical efficacy of the treatment of patients with gastric cancer (GC). Here we reported that transmembrane protein 160 (TMEM160) ...

State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China ...

Primary antibodies for COL1A1, RUNX2, AMPK, p-AMPK, GPX4, FTH, β-ACTIN, and Histone H3 were acquired from Cell Signaling Technology (United States), while primary antibodies for SLC7A11 and Nrf2 were ...

We have systematically summarized the effects of exercise on ferroptosis regulation through multiple molecular mechanisms, including upregulation of antioxidant defense systems via activation of NRF2, ...

糖尿病是一类由胰岛素分泌不足或胰岛素抵抗引起的代谢性疾病。通常分为1 型糖尿病（type 1 diabetes mellitus ，T1DM ）、T2DM 、妊娠糖尿病和其他原因导致的特定类型糖尿病。其中，T1DM 和T2DM是目前最常见的糖尿病类型。糖尿病发病机制复杂，包括胰岛β细胞功能 ...

we found that melittin attenuated ferroptosis in kidney tissue by enhancing GPX4 expression, which ultimately led to the reduction of kidney tissue injury. Furthermore, we observed that melittin ...

DIM induced ferroptosis in NSCLC cells; increased cellular Fe 2+, ROS (reactive oxygen species), and MDA; decreased cellular GSH, AHR, NRF2, and GPX4; and disrupted the mitochondrial membrane ...

研究还表明，Cory 通过 BAP1 调节 MPP + 处理的 SK-N-SH 细胞中核因子 E2 相关因子 2（NRF2）、血红素加氧酶 1（HO-1）和谷胱甘肽过氧化物酶 4（GPX4）的表达。Cory 通过调节 BAP1-NRF2/HO-1/GPX4 通路，减轻了 MPP + 诱导的人神经母细胞瘤细胞损伤，这可能为帕金森病的发展提供 ...

Myristicin regulates proliferation and apoptosis in oxidized low-density lipoprotein-stimulated human vascular smooth muscle cells and human umbilical vein endothelial cells by regulating the PI3K ...