褐藻糖胶通过激活 Nrf2 信号通路抑制 FFA 诱导的炎症反应 在 NAFLD 的发展过程中，炎症反应也是一个重要环节。研究人员发现，FFA 刺激会使 HepG2 细胞中 TNF-α 和 IL - 6 的表达上调，同时导致 P65 NF - κB 的磷酸化和核转位增加，引发炎症反应。而褐藻糖胶处理后 ...
This research aims to explore whether Berbamine (BBM) can mitigate tissue damage in mice resulting from hind limb muscle ischemia-reperfusion by scavenging lipid ROS and inhibiting p65 nuclear ...
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The System XC and GPX4 are vital in maintaining intracellular GSH levels, which are essential for ROS removal. Notably, SIRT1 functions as a sensor of redox changes and plays a critical protective ...
但顺铂治疗导致肿瘤组织中 Nrf2 激活显著增加。此外，BARD 治疗使肾脏中 NF - κB p50 激活增加，而顺铂治疗使肾脏和肿瘤组织中 NF - κB p65 激活增加，但 BARD 联合治疗未显著减轻这种增加。 BARD 不影响顺铂的抗肿瘤作用：研究还发现，Veh/CIS 和 BARD/CIS 组小鼠的肿瘤 ...
This study presents a valuable finding on the importance of the plasma metabolome in glaucoma risk prediction. The authors have used the UK Biobank data to interrogate the association between plasma ...
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Combined, these findings show that CMA displays a broad targetability on multiple steps of the EMT process and indicate a substantial role of CMA in regulating the stability of pro-metastatic and ...
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