Five of the conditions (xeroderma pigmentosum, Cockayne's syndrome, trichothiodystrophy, Down syndrome, and triple-A syndrome) display a defect in the nucleotide excision repair pathway ...

Abstract: Compelling evidence indicates that proliferating cell nuclear antigen (PCNA) is an indispensable factor not only in DNA replication but in nucleotide excision repair (NER), alternative ...

Scientists have tapped into the Summit supercomputer to study an elaborate molecular pathway called nucleotide excision repair (NER). This research reveals how damaged strands of DNA are repaired ...

Xeroderma pigmentosum (XP) is an autosomal recessive condition resulting from defects in the nucleotide excision repair pathway, causing heightened ultraviolet radiation sensitivity and significantly ...

The native structure of genomic DNA can be damaged in many ways, both by external agents and from within the cell as a consequence of normal metabolism In an effort to maintain their genomic ...

The Summit supercomputer revealed how damaged strands of DNA are surgically repaired by a molecular pathway called nucleotide excision repair, or NER. NER’s protein components can change shape to ...

Targeting Ewing sarcoma with a novel RBM39 degrader: DNA damage repair pathway effects [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular ...

Conversely, the downregulated pathways included: Aminoacyl-tRNA biosynthesis, Cell cycle, DNA replication, Fanconi anemia pathway, Homologous recombination, Mismatch repair, Nucleocytoplasmic ...