Prehospital resuscitative thoracotomy was feasible for traumatic cardiac arrest (TCA) in a mature, physician-led, urban system and was associated with improved survival, particularly when ...

研究结果如下： 琥珀酰辅酶 A 塑造抗肿瘤免疫：通过分析接受免疫治疗的黑色素瘤患者的蛋白质组数据，发现三羧酸循环（TCA 循环）和氧化磷酸化（OXPHOS）途径的高表达与更好的预后和免疫治疗反应相关。关键酶（OGDH、SCS 和 SDH）在免疫治疗应答者中丰富 ...

1Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas. 8Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas ...

Since intratumoral lactate could be transported into macrophages to support the tricarboxylic acid (TCA) cycle (Fang et al., 2023), we hypothesized that during the progression of KD, increased lactate ...

在能量代谢方面，缺氧降低了参与 TCA 循环、细胞质 - 线粒体运输和 ETC 活性的基因的转录组丰度，损害了能量产生，同时还诱导了 ROS 的升高，导致线粒体结构和功能受损。值得注意的是，葡萄糖摄取和甘油三酯合成依赖于 HIF-1α，而乳蛋白合成的减少则与 HIF-1α ...