Orthopnea can be defined as dyspnea that develops in the recumbent position and is relieved by elevation of the head with pillows. In the recumbent position, there is reduced pooling of fluid in ...

Self-reported clinical variables, such as orthopnea, are subjected to bias. In addition, this study cannot account for the possible influence of noncardiac causes of orthopnea. The history of ...

In the past few decades, considerable progress has been made in understanding the complex interaction of host and pathogen, and the pathophysiology underlying both meningococcal septicaemia and ...

Fibroblast growth factors (FGFs) signal through FGF receptor tyrosine kinases to regulate a wide range of biological processes during development and adulthood. FGF receptors (FGFRs) are involved ...

Functional dyspepsia is a symptom complex characterised by postprandial upper abdominal discomfort or pain, early satiety, nausea, vomiting, abdominal distension, bloating, and anorexia in the absence ...

Division of Sleep Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA Correspondence to: Dr R B Fogel Division of Sleep Medicine, Brigham and Women’s Hospital, Harvard ...

Although the evidence supporting interventions for each mechanism is not at the same level of proof, the current state-of-the-art provides the opportunity to advance the practice from treatment based ...

This is an unusual phenomenon that is rarely described in the literature, and its optimal management remains controversial. This report reviews the clinical considerations for this rare ...

The problem of the pathophysiology of unstable angina lies in patients who have milder and persistent rest pain over months or even years. The perception is that these cases are related to vasomotor ...

Despite this intervention, the patient's symptoms worsened, manifesting as chest tightness, cough, dyspnea, lower limb edema, and orthopnea. As a result, the clinician expanded the diagnosis to ...