骨肉瘤（OS）治疗中，顺铂（DDP）单药疗效不佳且副作用大。为解决此问题，研究人员开展了豆蔻（CAR）与 DDP 联合治疗 OS 的研究。结果显示，二者联合可协同抑制 OS 细胞生长，机制与 mTOR 介导的自噬有关，这为 OS 治疗提供了新策略。

自噬是细胞将受损、变性或衰老的蛋白质及细胞器运输到溶酶体，并通过溶酶体的消化降解来清除这些物质的过程。作为一种自我降解的机制，自噬在细胞内普遍存在，发挥着重要作用，特别是在清除代谢废物和提供能量支持细胞正常功能方面。 一、自噬分类 ...

Background: Neuraminidase-1 (NEU1) is an enzyme that breaks down sialic acids on glycoproteins and glycolipids. Aberrant expression of NEU1 has been linked to the progression of numerous malignancies, ...

IHC staining to assess the positive rate of Bax and cleaved caspase-3 in brain tissue; (G) Western blot to detect the expression of ATG5 and P62 in brain tissue; (H) ELISA to detect the levels of ...

The Islamabad High Court (IHC) has sought a record from Adiala Jail superintendent regarding visitor meetings with Pakistan Tehreek-e-Insaf founder Imran Khan. A three-member IHC bench headed by ...

ISLAMABAD: The Islamabad High Court (IHC) on Monday ordered the consolidation of various cases to meeting rights of Pakistan Tehreek-e-Insaf (PTI) founder Imran Khan who's incarcerated in Adiala jail.

Background: Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) is an E3 ubiquitin ligase and scaffolding protein that contribute to the progression of various malignant tumors. However, ...